Muscle Specific Kinase Antibodies (MUSK) – Referral

Code:
MUSK

Sample Type:

2mL Serum (Gel 5mL Yellow tube)

Ref Ranges/Units:

Normal is Negative.

Normal result = Negative

Turnaround:

4-6 weeks

Frequency of Analysis: Referred to Oxford (sent every day except Friday)

Special Precautions/Comments:

Method: Sent away to: Oxford University Hospital

Interferences: None known

Additional Information:

Indication: Myasthenia Gravis in ACR negative patients.

Background Information: MuSK antibodies are involved in the pathogenesis of acetylcholine receptor antibody negative myasthenia gravis, this is more common in adults than children. MuSK antibodies have been shown to be present in 35-70% of adult Myasthenia patients that have negative acetylcholine receptor antibodies (ACR antibodies) [1].

References: Anlar B, Imaz VY, Saruhan-Direskeneli G. Long remission in muscle specific kinase antibody positive juvenile myasthenia. Paediatric Neurology. 2009. 40(6):455-456. [Ref 1] Vincent A, Leite MI. Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis. Current Opinions in Neurology. 2005. 18(5):519-525

See Also: Acetylcholine receptor antibodies

Telephone Gateshead Lab: 0191.4456499 Option 4, Option 1

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