Special Precautions/Comments:

Interferences: None known

Interpretations: These antibodies are of limited clinical significance. Discuss with senior clinical scientist/medical staff. Results are reported as either: NEGATIVE or POSITIVE, with pattern as follows:- 1. Striational. A striational pattern is seen in both cardiac and skeletal muscle but sometimes seen more prominently in skeletal muscle than cardiac muscle. This may be associated with Myasthenia Gravis and thymoma (See skeletal muscle). 2. Myocardial. If myocardial antibodies are positive, the pattern is reported as anti-sarcolemmal or anti-fibrillary

 

Additional Information:

Indication: Dressler’s syndrome, post-MI.

Background: Cardiac muscle antibodies are described in patients with Dressler’s syndrome after myocardial infarction, cardiomyopathy, myocarditis and in patients who have undergone cardiac surgery or have had rheumatic fever. They can be directed towards a number of antigens such as adenine nucleotide translocator protein, cardiac myosin and tropomysin. The presence of antibodies can occur without the Dressler syndrome

References: Jahns R, Boivin V, Schwarzbach V et al. Pathological autoantibodies in cardiomyopathy. Autoimmunity. 2008. 41(6):454-461. [Ref 1] Okasaki T, Honjo T. Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy. Trends Mol Med. 2005. 11(7):322-326. [Ref 2] Caforio AL, Daliento L, Angelini A et al. Autoimmune myocarditis and dilated cardiomyopathy: focus on cardiac autoantibodies. Lupus. 2005. 14(9):652-655

See Also: Skeletal Muscle

Telephone Gateshead Lab: 0191.4456499 Option 4, Option 1