Special Precautions/Comments:

Additional Information:

Consultant Approved Referral Test

Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years
ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a
neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection. Consultant Approved Referral Test Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection. Consultant Approved Referral Test Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection. Consultant Approved Referral Test Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection. Consultant Approved Referral Test Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection. Consultant Approved Referral Test Autoimmune Neutropenia (ANI) is a rare clinical condition caused by granulocyte autoantibodies, which may occur either in children or adults but which often remains undiagnosed. Autoimmune neutropenia commonly occurs in children between the ages of 6 months and 5 years ANI tends to be a self-limiting autoimmune condition but can last several years. In adult patients, AIN presents as a chronic disorder either as an isolated (primary) neutropenia or as a neutropenia secondary to other disorders, such as rheumatoid arthritis, systemic lupus erythematosus, Felty s syndrome and chronic lymphocytic and large granulocytic leukaemias. These investigations are only indicated if the patient has a neutrophil count < 2.0 x 109/L and the results will affect clinical management. Referrals without a stated neutrophil count or if the neutrophil count is >2.0×109/L or if inadequate clinical information is provided may not be investigated. Direct tests cannot be performed on
patients with a neutrophil count < 0.4 x 109/L or if the patient has received G-CSF or IVIGG within the previous 3 weeks. Granulocytes are labile cells that deteriorate rapidly in vitro. Consequently, blood samples for direct tests must reach the referral laboratory within 24 hours of venesection.