Special Precautions/Comments:

N.B. Please ensure travel history is indicated in clinical details.

Method:  Real-time polymerase chain reaction (PCR) for the detection of Epstein-Barr Virus DNA. Calibration: – EQA scheme: UKNEQAS IQC: –

Interpretation: Unless otherwise requested, blood samples will be tested using a multiplex PCR assay for the detection of Cytomegalovirus (CMV), Epstein-Barr Virus (EBV) and Adenovirus (AD). Results are reported as NOT detected or DETECTED by PCR. A negative result does NOT fully exclude infection.

For further information contact Department of Microbiology, Newcastle Laboratories, Freeman Hospital.

Additional Information:

Background information: The Epstein-Barr virus (EBV) is ubiquitous. It was identified as the cause of infectious mononucleosis (IM). In adolescents and young adults, EBV may cause an infectious mononucleosis still known as Pfeiffer’s disease (glandular fever) or the kissing disease. In young children, EBV infection is usually asymptomatic.

Detection of EBV DNA by PCR can aid the diagnosis and monitoring of immunocompromised patients, who are at risk of EBV related disorders, such as Post Transplant Lymphoproliferative Disease (PTLD).