Lupus Anticoagulant.
Code:
L.A.
Sample Type:
Blue top tube
Ref Ranges/Units:
Patient results are expressed as a normalized ratio and are calculated at each test run. In principle:
Negative results – patients with a normalized ration <1.15, and APTTS reported within normal reference range will be reported as ‘Lupus Anticoagulant not detected.’
Results suggestive of a Positive L.A. Screen – patients with a normalized ratio >1.20, APTTS above the normal range will be reported as ‘Results suggest the presence of Lupus Anticoagulant.’
Once a patient has been identified as positive for lupus anticoagulant it is advised that testing be repeated on a second occasion >12 weeks after the initial testing.
Positive, borderline or negative patients with abnormal APTTS will be forwarded to consultants for review – reports issued as interpretive comment.
Patient results are expressed as a normalized ratio and are calculated at each test run. In principle:
Negative results – patients with a normalized ration <1.15, and APTTS reported within normal reference range will be reported as ‘Lupus Anticoagulant not detected.’
Results suggestive of a Positive L.A. Screen – patients with a normalized ratio >1.20, APTTS above the normal range will be reported as ‘Results suggest the presence of Lupus Anticoagulant.’
Once a patient has been identified as positive for lupus anticoagulant it is advised that testing be repeated on a second occasion >12 weeks after the initial testing.
Positive, borderline or negative patients with abnormal APTTS will be forwarded to consultants for review – reports issued as interpretive comment.
Patient results are expressed as a normalized ratio and are calculated at each test run. In principle:
Negative results – patients with a normalized ration <1.15, and APTTS reported within normal reference range will be reported as ‘Lupus Anticoagulant not detected.’
Results suggestive of a Positive L.A. Screen – patients with a normalized ratio >1.20, APTTS above the normal range will be reported as ‘Results suggest the presence of Lupus Anticoagulant.’
Once a patient has been identified as positive for lupus anticoagulant it is advised that testing be repeated on a second occasion >12 weeks after the initial testing.
Positive, borderline or negative patients with abnormal APTTS will be forwarded to consultants for review – reports issued as interpretive comment.
Turnaround:
7 Days
Special Precautions/Comments:
Additional Information:
Lupus anticoagulants are antibodies against negatively charged phospholipids or complexes of phospholipids. They may occur in various clinical conditions, particularly autoimmune diseases and are now considered to be a significant risk factor in patients with unexplained thrombosis and are often present in women with recurrent foetal loss. The guidelines do not recommend performing LA tests on patients on any type of anticoagulant, including oral anticoagulants and NOAC’s.
Haemolysed samples may give false results and therefore will not be used.
Lupus anticoagulants are antibodies against negatively charged phospholipids or complexes of phospholipids. They may occur in various clinical conditions, particularly autoimmune diseases and are now considered to be a significant risk factor in patients with unexplained thrombosis and are often present in women with recurrent foetal loss. The guidelines do not recommend performing LA tests on patients on any type of anticoagulant, including oral anticoagulants and NOAC’s.
Haemolysed samples may give false results and therefore will not be used.
Lupus anticoagulants are antibodies against negatively charged phospholipids or complexes of phospholipids. They may occur in various clinical conditions, particularly autoimmune diseases and are now considered to be a significant risk factor in patients with unexplained thrombosis and are often present in women with recurrent foetal loss. The guidelines do not recommend performing LA tests on patients on any type of anticoagulant, including oral anticoagulants and NOAC’s.
Haemolysed samples may give false results and therefore will not be used.
South of Tyne & Wear Pathology Centre
