N-Methyl-D-Aspartate Receptor Antibodies / NMDAR – Referral

Code:
NMDA

Sample Type:

2mL Serum (Gel 5mL Yellow tube)

Ref Ranges/Units:

A normal result is negative

 

 

Turnaround:

3-4 weeks

Frequency of Analysis: Referred to RVI Newcastle

Special Precautions/Comments:

Method: Sent away to: Oxford University Hospital

Interferences: None known.

Additional Information:

Indication: Cerebral dysfunction. Paraneoplastic encephalitis associated with immature teratoma of the ovary

Background Information: In women younger than 45 years, a form of encephalitis associated with ovarian teratoma and presenting with seizures and psychiatric symptoms has been described. Most patients have antibodies to NR1/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR) [1].

References: Wang W, et al. Neural cell cycle dysregulation and central nervous system diseases. Progress in Neurobiology. 2009. 89(1):1-17. Neihusmann P, et al. Diagnostic value of N-methyl-D-aspartate antibodies in women with new-onset epilepsy. Archives of Neurology. 2009. 66(4):458-464. [Ref 1]

Telephone Gateshead Lab: 0191.4456499 Option 4, Option 1

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