Tacrolimus
Code:
TAC
Sample Type:
Whole Blood EDTA (Purple Top)
Minimum volume: 1 mL
Ref Ranges/Units:
Most individuals show an optimal response with a trough level of 8-12 ng/mL.
However, ranges vary depending on type of transplant and length post-transplant.
<3 or >15 ng/mL phoned to the requesting clinician or on-call transplant consultant.
Turnaround:
Referral test – same/next day for urgent samples
Special Precautions/Comments:
Trough sample recommended (blood drawn immediately before scheduled dose).
Additional Information:
Tacrolimus is an immunosuppressant drug used to prevent rejection after solid organ transplantation. Studies suggest tacrolimus has clinical advantages over cyclosporin with fewer side effects and decreased occurrence of acute rejection. It has a narrow therapeutic window and is associated with many side effects. Therapeutic drug monitoring is therefore essential to optimise immunosuppression, minimise adverse effects and check patient compliance.
South of Tyne & Wear Pathology Centre
